As a Musculoskeletal Radiologist, I try to identify the cause of one's pain, discomfort, inflammation or other related musculoskeletal symptom(s) using clinical imaging approaches such as magnetic resonance imaging (MRI), computed tomography, digital radiography & ultrasound. However, these current approaches have limitations in accurately identify pain generators. Accordingly, my group along with my collaborators have been developing clinical imaging methods that would objectively pinpoint the site of pain generation using novel agents that specifically seek out molecular and cellular pain markers to highlight hypersensitive pain-sensing nerves.