Guthrie medical office, headquartered in Sayre, Pa., is one of the nation's first multispecialty group practices. Today more than 220 specialty physicians and providers practice in Guthrie's large multispecialty Sayre, Pa. facility, which serves as a major regional specialty care referral center. Guthrie board-certified specialty physicians and surgeons have experience and expertise in the latest diagnostic and treatment advances in more than 50 areas of medicine.